NAT2

NAT2

NAT2 is in the colon, liver and small intestine. The enzyme N-acetyltransferase 2 acts primarily in the liver to detox several chemicals, caffeine, toxins, and prescription drugs. Depending on all your other NAT2 SNPs you can determine/alter your NAT2 phenotype (slow/fast acetylators). Variants can cause the carrier to be a slow acetylator, where toxins do not clear as well and wild type carriers tend to be fast acetylators which can cause toxins to be more reactive and make mistakes. Acetylation can also change cholesterol levels too high or low if the acetylation pathway is not functioning properly.